Dr. Vikram Saini's Lab
(Laboratory of Infection Biology and Translational Research)
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  List of Publications

    Year : 2023

  1. Richa, Kiran, Kushwaha N, Jaiswal E , Kumar A, Kaur J, Sharma S, Jain A, Sindhu J, Mehta SK, Saini V, Kataria R (2023). Mixed ligand approach for novel hydrazide copper (II) complexes: Structural aspects, theoretical investigation and their biological evaluation. Applied Organometallic Chemistry 37 (7), e7118

  2. Kumar A, Negi S, Choudhary T, Mutreja V, S Sunaina, Sahoo SC, Singh A, Mehta SK, Kataria R, Saini V (2023). A highly sensitive and specific luminescent MOF determines nitric oxide production and quantifies hydrogen sulfide-mediated inhibition of nitric oxide in living cells. Microchimica Acta. PMID: 36897440

  3. Kumar A, Kushwaha N, Sharma S, Mutreja V, Jain A, SC, Singh A, Mehta SK, Saini V and Kataria R. Mixed ligand approach for novel hydrazide copper(II) complexes: Structural aspects, theoretical investigation and their biological evaluation. Applied Organometallic Chemistry. 23 April 2023 https://doi.org/10.1002/aoc.7118

  4. Kumar A, Negi S, Chaudhary T, Mutreja V, Sunaina, Sachoo SC, Singh A, Mehta SK, Kataria R and Saini V* (2023). A highly sensitive and specific luminescent MOF determines NO production and quantifies Hydrogen sulfide mediated inhibition of NO in living cells. Microchimica Acta 190, 127 (2023). https://doi.org/10.1007/s00604-023-05660-y.

    5. Year : 2022

  5. Kumar S, Ahmad A, Kushwaha N, Shokeen N, Negi S, Gautam K, Singh A, Tiwari P, Garg R, Agarwal R, Mohan A, Trikha A, Thakar A and Saini V* (2022). Selection of appropriate reference genes for normalization of qRT-PCR based gene expression analysis in SARS-CoV-2, and Covid-associated Mucormycosis infection. Microbiology Spectrum. e01656-22.
    PMID: 36377893

  6. Kumar S, Raj S, Ahmad A, and Saini V* (2022). Amoxicillin modulates gut microbiota to improve short-term high-fat diet induced pathophysiology in mice. Gut Pathogens, 14, 40.
    PMID: 36229889

    7. Year : 2021

  7. $ *Saini V, Kalra P, Sharma M, Rai C, Saini Vikas, Gautam K, Bhattacharya S, Mani S, Saini K, Kumar S (2021). A cold chain independent specimen collection and transport medium improves diagnostic sensitivity, and minimizes biosafety challenges of Covid19 molecular diagnosis. Microbiology Spectrum. 9, e01108-21. $Patent filed.
    PMID: 34878310

    Research Highlight in Nature India: Microbial transport medium improves COVID-19 diagnostic. https://www.nature.com/articles/d44151-022-00003-x

    Innovative Product/device Award (First) from All India Institute of Medical Sciences (AIIMS), New Delhi on the 2nd Annual Research Day 2022

  8. Kumar P, Saini K, *Saini V, *Mitchell T (2021). Oxalate Suppresses macrophage immunometabolism and anti-bacterial response to uropathogenic E. coli (UPEC) infection. Frontiers in Immunology. Vol 12, Article 694865. https://doi.org/10.3389/fimmu.2021.694865
    PMID: 34745086


  9. FNU Kirandeep, Kumar A, Sharma A, Sahoo SC, Zangrando E, Saini V, Kataria R, Mehta S K (2021). Metal organic framework as “Turn-On” fluorescent sensor for Zr (IV) ions and selective adsorbent for organic dyes. MicroChemical Journal. https://doi.org/10.1016/j.microc.2021.106824 (online Sept 13, 2021).

  10. Kunota TTR, Rahman MA, Truebody BE, Mackenzie JS, Saini V, Lamprecht DA, et al.(2021) Mycobacterium tuberculosis H2S Functions as a Sink to Modulate Central Metabolism, Bioenergetics, and Drug Susceptibility. Antioxidants. 10 (8):1285.
    PMID: 34439535

  11. $Richa FNU, Kushwaha N, Negi S, Kataria R, and Saini V* (2021). Synthesis, characterization, and utility of a series of novel copper (II) complexes as excellent surface disinfectants against nosocomial infections. Dalton Transactions. DOI: 10.1039/D1DT00199J. Back Cover Page Article. $Patent filed.

  12. Gautam K, Negi S and Saini V* (2021). Targeting endogenous gaseous signaling molecules as novel Host-directed therapies against tuberculosis infection. Free Radical Research. Page 1-16, DOI: 10.1080/10715762.2021.1892091

  13. Kapoor P, Chowdhury A; Kharbanda O.P.; Bablani D. P., Gautam K, and Saini V (2021). Exploring Salivary Diagnostics in COVID-19: A Scoping Review and research suggestions. BDJ (British Dental Journal) Open. Vol. 7, Article number: 8. https://doi.org/10.1038/s41405-021-00064-7. Featured in Readers' Choice: The best of BDJ Open 2021 (the most accessed articles of journal)

  14. Saini V* and Kalra P (2020). An illustrated step-by-step guide to establish a disinfection facility for reuse of personal protective equipment. Protocol Exchange. DOI:10.21203/rs.3.pex-1082/v1.

    15. Year : 2020

  15. Gupta P, Dutt V, Kaur N, Kalra P, Gupta S, Dua A, Dabur R, Saini V, and Mittal A. S-allyl Cysteine: A Potential Compound against Skeletal Muscle Atrophy (2020). BBA - General Subjects (Accepted).
    PMID: 32649980

  16. Taneja V, Kalra P, Goel Manish, Khilnani GC, Saini V, Prasad GBKS, Gupta UD, and Prasad HKP (2020). Impact and Prognosis of the Expression of IFN-α Among Tuberculosis Patients. PLos One.
    https://doi.org/10.1371/journal.pone.0235488

    PMID: 32667932

  17. Saini V*, Sikri K, Batra SD, Kalra P and Gautam K. Development of a highly effective low-cost vaporized hydrogen peroxide-based method for disinfection of personal protective equipment for their selective reuse during pandemics (2020). Gut Pathogens. 12:29. (Corresponding author).
    PMID: 32572338

  18. Vashishta D, Sharma S, Kumar R, Saini Vaneet, Saini V, Ibhadonc A, Sahoo SC, Sharma S, Mehta S K, Kataria R (2020). Dehydroacetic acid derived Schiff base as selective and sensitive colorimetric chemosensor for the detection of Cu (II) ions in aqueous medium. Microchemical Journal, 155, 104705.

  19. Saini, V, Chinta, K.C., Reddy, V.P. et al. Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis. Nature Communications.(2020) doi:10.1038/s41467-019-14132-y
    This noxious gas aggravates TB
    PMID: 31992699

    20. Year : 2017-2019

  20. Chinta K, Rahman A, Saini V, Glasgow J, Reddy VP et al. (2019) Microanatomic distribution of myeloid Heme Oxygenase-1 protects against free radical-mediated immunopathology in human tuberculosis. Cell Reports, 25 (7), 1938-1952. e5. (Cover page article).
    PMID: 30428359

  21. Gupta P, Kaur N, Saini V, Bala M, Sherawat S, Gupta S, Dua A, Kumar V, Dutt V, Injeti Elisha, Mittal A. (2019) Cinnamaldehyde regulates H2O 2‐induced skeletal muscle atrophy by ameliorating the proteolytic and antioxidant defense systems. Journal of Cellular Physiology, 234 (5), 6194-6208.
    PMID: 30317570

  22. Patel M, Yarlagadda V, Adedoyin O, Saini V, Oreoluwa D, Holmes R, Mitchell T. (2018) Oxalate induces mitochondrial dysfunction and disrupts redox homeostasis in a human monocyte derived cell line. Redox Biology. Vol. 15, 207-215.
    PMID: 29272854

  23. HT Pacl, VP Reddy, V Saini, KC Chinta, AJC Steyn. (2018) Host-pathogen redox dynamics modulate Mycobacterium tuberculosis pathogenesis. Pathogens and Disease, 76 (5), fty036.
    PMID: 29873719

  24. Dutt V, Saini V, Gupta P, Kaur N, Bala M, Gujar R, Grewal A, Gupta S, Dua A, Mittal A (2018). S-allyl cysteine inhibits TNF alpha induced skeletal muscle wasting through suppressing proteolysis and expression of inflammatory molecules. Biochim Biophys Acta. (Gen Subjects); Vol. 1862 (4): 895-906.
    PMID: 29288771

  25. Kumar S, Saini V, Maurya IK, Kumari M, Kataria R, Gupta GK, Kumar V (2018). Design, synthesis, DFT, docking studies and ADME prediction of some new coumarinyl linked pyrazolylthiazoles: Potential standalone or adjuvant antimicrobial agents. PLoS One. 13(4): e0196016.
    PMID: 29672633

  26. Reddy VP, Chinta KC, Saini V, Glasgow JN, Hull T, Traylor A, Rey-Stolle F, Soares M, Barbas C, Nargan K, Naidoo T, Ramdial PK, George JF, Agarwal A, Steyn AJC (2018). Ferritin H deficiency in myeloid compartments dysregulates host energy metabolism and increases susceptibility to M. tuberculosis infection. Frontiers in Immunology. Vol. 9, e 00860 (26 pages).
    PMID: 29774023

  27. Cumming B, Rahman A, Lamprecht D, Rhode K, Saini V, Russell D, Steyn AJC (2017). Mycobacterium tuberculosis arrests host cycle at the G1/S transition to establish long term infection. PLoS Pathogens 13 (5), e1006389.
    PMID: 28542477

  28. Talwar GP, Gupta JC, Mustafa AS, Zaheer SA, Choudhury, Kar HK, Katoch K, Katoch VM, Parida S, Reddy P, Ahmed N, Saini V, Gupta S (2017). Development of a potent invigorator of immune responses endowed with both preventive and therapeutic properties. Biologics: Targets and Therapy (11), 55—63.
    PMID: 28496303

    29. Year : 2014-2016

  29. Chinta K, Saini V, Glasgow J, Mazorodze J, Rahman A, Reddy D, Lancaster J, Steyn AJC (2016). The emerging role of gasotransmitters in the pathogenesis of tuberculosis (2016). Nitric Oxide. Vol. 59, 28-41.
    PMID: 27387335

  30. Saini V,Cumming BM, Guidry L, Lamprecht D, Adamson JH, Reddy VP, Chinta KC, Mazorodze J, Glasgow JN, Richard-Greenblatt M, Gomez-Velasco A, Bach H, Av-Gay Y, Eoh H, Rhee K, Steyn AJC (2016). Ergothioneine maintains redox and bioenergetichomeostasis essential for drug susceptibility and virulence of Mycobacterium tuberculosis. Cell Reports. Vol.14, 1-14.
    PMID: 26774486

  31. Cumming BM, Lamprecht D, Wells RM, Saini V, Mazorodze J, Steyn AJ (2014). The physiology and genetics of oxidative stress in mycobacteria. Microbial Spectrum. Vol. 2 (3), 1-22.
    PMID: 26103972

    32. Year : 2011-2013

  32. AJC Steyn, D Mai, V Saini, A Farhana.(2013) Protein–Protein Interaction in the -Omics Era: Understanding Mycobacterium tuberculosis Function. Systems Biology of Tuberculosis, 79-106.

  33. Farhana A, Saini V, Kumar A, Lancaster J, Steyn AJC (2012). Environmental heme sensor proteins: Implications for understanding bacterial pathogenesis. Antioxidants and Redox signaling. Vol. 17 (9), 1232-1245.
    PMID: 22494151

  34. Saini V, Raghuvanshi S, Ahmed N, Khurana JP, Hasnain SE, Tyagi Akhilesh K, Tyagi Anil K (2012). Massive gene acquisitions in Mycobacterium indicus pranii provide a perspective on mycobacterial evolution.Nucleic Acids Res. doi: 10.1093/nar/gks793.Vol. 40 (21) 10832-10850.
    PMID: 22965120

    This is the first new bacterial species completely sequenced in India. Selected as a breakthrough article by NAR editorial board representing the top 5% of studies in terms of originality, significance and scientific excellence.

    Commentary at Nature: 'Mosaic genome' holds clue to TB, leprosy vaccines
    http://www.nature.com/nindia/2012/120921/full/nindia.2012.137.html

  35. Regev D, Surolia R, Karki S, Zolak J, Montes-Worboys A, Oliva O, Guroji P, Saini V, Steyn AJC, Agarwal A and Antony V (2012). Heme oxygenase-1 promotes granuloma development and protects against dissemination of mycobacteria. Laboratory Investigation. doi:10.1038/labinvest.2012.125. Vol. 92 1541-52.
    PMID: 22964851

  36. Saini V, Farhana A, Glasgow JN, Steyn AJC (2012). Iron sulfur cluster proteins and microbial regulation: Implications for understanding tuberculosis.
    Current Opinion in Chemical Biology. Vol. 16 (1-2), 45-53.
    PMID: 22483328

  37. Kumar A, Farhana A, Guidry L, Saini V, Hondulas M, Steyn AJC (2011). Redox homeostasis in mycobacteria: the key to tuberculosis control? Expert reviews in Molecular Medicine. Vol. (13): e39. DOI: 10.1017/S1462399411002079. (25 pages)
    PMID: 22172201

  38. Saini V, Farhana A, Steyn AJC (2011). Mycobacterium tuberculosis WhiB3: A novel iron-sulfur cluster protein that regulates redox homeostasis and virulence. Antioxidants and Redox signaling. Vol 16 (7) 687-697.
    PMID: 22010944

    39. Year : 2007-2010

  39. Saini V, Raghuvanshi S, Ahmed N, Talwar GP, Khurana JP, Hasnain SE, Tyagi Akhilesh K, Tyagi Anil K (2009). Polyphasic taxonomic analysis establishes Mycobacterium indicus pranii as a distinct species. PLoS ONE 4(7): e6263.doi: 10.1371/journal.pone. 0006263 (10 pages)
    PMID: 19606228

  40. Talwar GP, Ahmed N, Saini V (2008). The use of the name Mycobacterium w for the leprosy immunotherapeutic bacillus creates confusion with M. tuberculosis-W (Beijing strain): A suggestion. Infect Genet Evol. Vol. 8(1), 100-101.
    PMID: 17766188

  41. Ahmed N*, Saini V*, Raghuvanshi S, Khurana JP, Tyagi Akhilesh K, Tyagi Anil K, Hasnain SE (2007). Molecular analysis of a leprosy immunotherapeutic bacillus provides insights into Mycobacterium evolution. PLoS ONE 2(10): e968. doi:10.1371/journal.pone.0000968.). (8 pages).
    PMID: 17912347

   List of Full Publications:

   Google Scholar Link :-

    https://scholar.google.com/citations?user=zE4kGlwAAAAJ&hl=en


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